LY 294002 from Promega

Product Specs
ItemLY 294002
CompanyPromega
Price Supplier Page View Company Product Page
Catalog NumberV1201
TargetPI3 Kinase, DNA-PKc
Quantity5mg

Specifications/Features

Ki, IC, EC, or working concentration: IC₅₀ = 1 – 50µM

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Promega

2800 Woods Hollow Rd.

Madison, Wisconsin

United States

Phone: 800-356-9526
Fax: 800-356-1970

Company Profile

Website: http://www.promega.com

(1) Bovine tumor necrosis factor-alpha Increases IL-6, IL-8, and PGE2 in bovine fibroblast-like synoviocytes by metabolic reprogrammingScientific ReportsFebruary 24, 2023Carolina Manosalva, Pablo Alarcon, John Quiroga, Stefanie Teuber, Maria D. Carretta, Hedie Bustamante, Rodrigo Lopez-Muñoz, Maria A. Hidalgo, Rafael A. BurgosUSA) was performed in medium containing 5.5 mM glucose for 1 h. Pretreatment with 10 μM LY294002 (#V1201, Promega, Madison, WI, USA) and 20 μM FX11 (#HY-16214. MedChemExpress, Monmouth Junction, NJ, USA) and

(2) Nur77-Tempo mice reveal T cell steady state antigen recognitionDiscovery ImmunologyDecember 22, 2022Thomas A. E. Elliot, Emma K. Jennings, David A. J. Lecky, Sophie Rouvray, Gillian M. Mackie, Lisa Scarfe, Lozan Sheriff, Masahiro Ono, Kendle M. Maslowski, David Bending,Thermo Fisher,00-4333-57 OptiPrep,Sigma,D1556 DMSO,Sigma,D2650-100ML PP2,Sigma–Aldrich,P0042-5MG GO 6983,Cambridge Bioscience,SM20-1 SP600125,Sigma–Aldrich,S5567-10MG Ly 294002,Promega,V1201 PD0325901,Cambridge Bioscience,SM26-2 Cyclosporin A,Cambridge Bioscience,SM43-50 Genomic DNA Mini

(3) Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesisNature CommunicationsAugust 4, 2022Mostafa Bakhti et al.treated with 14 µM PIP3/protein binding inhibitor (PIT-1) (Abcam, ab120885) or 10 µM LY294002 (Promega, V1201). The medium was replaced with a fresh one every 24 h. Samples were fixed and stained after 2 days in

(4) Metabolic Reprogramming and Inflammatory Response Induced by D-Lactate in Bovine Fibroblast-Like Synoviocytes Depends on HIF-1 ActivityFrontiers in veterinary scienceJanuary 1, 2021Quiroga J, Alarcón P, Manosalva C, Teuber S, Taubert A, Hermosilla C, Hidalgo MA, Carretta MD, Burgos RA.(#10010266, Cayman Chemicals, Ann Arbor, MI, USA) to inhibit the NF-κB activity; and (c) 10 µM LY294002 (#V1201, Promega, Madison, WI, USA) to inhibit the PI3K/Akt signaling pathway. DMSO (0.1%) was used as vehicle

(5) Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expressionNature CommunicationsDecember 1, 2020Anna S. E. Cuomo et al.80 ng/mL FGF2 (made in house), 10 ng/mL BMP4 (R&D systems, #314-BP-050), 10 µm Ly294002 (Promega, #V1201), and 3 µM CHIR99201 (Selleckchem, #S1263) for 24 h (Day 1). After 24 h, the day 1 media was replaced

(6) Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic VariationCell stem cellSeptember 3, 2020Ortmann D, Brown S, Czechanski A, Aydin S, Muraro D, Huang Y, Tomaz RA, Osnato A, Canu G, Wesley BT, et al.D,Cat#314-BP CHIR99021,Tocris Bioscience,Cat#4423/10 PD0325901,Tocris Bioscience,Cat#4192 LY294002,Promega,Cat#V1201 Retinoic Acid,Sigma,R2625 IWP2,Tocris,Cat# 3533/10 ,, Critical Commercial Assays,Critical Commercial

(7) A homogeneous bioluminescent immunoassay to probe cellular signaling pathway regulationCommunications biologyJanuary 1, 2020Hwang BB, Engel L, Goueli SA, Zegzouti H.Tamoxifen (#6342) and Fulvestrant (#1047), were purchased from Tocris. MG132 (#G932) and LY294002 (#V1201) were obtained from Promega. The NanoBiT cell-based immunoassay components include Nano-Glo® Luciferase Assay

(8) Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repairNucleic acids researchJune 1, 2018Shah P, Zhao B, Qiang L, He YY.μM, Selleck Chemicals, S2248), KU-60019 (1 μM, Selleck Chemicals, S1570), LY294002 (10 μM, Promega, V1201), NU7441 (1 μM, Selleck Chemicals, S2638), TCS JNK 60 (10 μM, Torcis, 3222), SB203580 (10 μM, Promega,

(9) Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal ProgenitorsStem cell reviewsAugust 1, 2017Sambi M, Chow T, Whiteley J, Li M, Chua S, Raileanu V, Rogers IM.,R&D Systems,212-GD-010 GlutaMAX™,Invitrogen Life Technologies,35050–061 KO/DMEM,GIBCO,10829–018 LIF,In house, LY294002,Promega,V1201 Na pyruvate,Invitrogen,11360–070 NEAA,Invitrogen,11140–050 PenStrep,GIBCO,15140–122 RA,Calbiochem,554720 Serum

(10) Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cellsNature protocolsApril 1, 2017Sampaziotis F, de Brito MC, Geti I, Bertero A, Hannan NR, Vallier L.314-BP) Recombinant human FGF basic, 146 aa (R&D Systems, cat. no. 233-FB) LY294002 (Promega, cat. no. V1201) CHIR99021 (Tocris, cat. no. 4423) SB431542 (Tocris bioscience, cat. no. 1614) Recombinant Human Keratinocyte

(11) Hepatitis B core antigen upregulates B7-H1 on dendritic cells by activating the AKT/ERK/P38 pathway: a possible mechanism of hepatitis B virus persistenceLaboratory InvestigationNovember 1, 2016Man Li, Zhen-Hua Zhou, Xue-Hua Sun, Xin Zhang, Xiao-Jun Zhu, Shu-Gen Jin, Ya-Ting Gao, Yun Jiang, Yue-Qiu Gaoh, Mo-DC was collected and B7-H1 expression was examined by flow cytometry and western blotting. LY294002 (V1201), U0126 (V1121) and SB203580 (V1161) were purchased from Promega Corporation. SP600125 (s5567) was purchased from

(12) The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineagesThe Journal of cell biologyOctober 24, 2016Zhu L, Gomez-Duran A, Saretzki G, Jin S, Tilgner K, Melguizo-Sanchis D, Anyfantis G, Al-Aama J, Vallier L, Chinnery P, et al.media + 100 ng/ml Activin A + 80 ng/ml FGF2 + 3 µM CHIR99021 (CT99021; Stratech Scientific) + 10 µM LY (V1201; Promega) + 10 ng/ml BMP4 (R&D Systems), followed by day 2 media, consisting of CDM-PVA media + 100

(13) Production of hepatocyte-like cells from human pluripotent stem cellsNature ProtocolsFebruary 22, 2013Nicholas R F Hannan, Charis-Patricia Segeritz, Thomas Touboul, Ludovic VallierOncostatin M (R&D Systems 295-OM) Hepatocyte Growth Factor (Peprotech 100-39) LY294002 (Promega V1201) CHIR99021 (StemGent 04-0004) Fibroblast Growth Factor 10 (FGF10) (Autogen Bioclear ABC144) Transferrin

(14) HBcAg induces PD-1 upregulation on CD4+T cells through activation of JNK, ERK and PI3K/AKT pathways in chronic hepatitis-B-infected patientsLaboratory InvestigationFebruary 1, 2012Man Li, Xue-Hua Sun, Xiao-Jun Zhu, Shu-Gen Jin, Zhen-Jun Zeng, Zhen-Hua Zhou, Zhuo Yu, Yue-Qiu Gao48 h, T cells were collected and PD-1 expression was examined by FCM and western blotting. LY294002 (V1201), U0126 (V1121) and SB203580 (V1161) were purchased from Promega Corporation. SP600125 (s5567) was purchased

(15) Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-?B through Akt and p38 inhibition in RAW 264.7 macrophage cellsEuropean Journal of PharmacologyJune 22, 2006Ho Gyoung Kim, Bhushan Shrestha, So Yeon Lim, Deok Hyo Yoon, Woo Chul Chang, Dong-Jik Shin, Sang Kuk Han, Sang Min Park, Jung Hee Park, Hae Il Park, Jae-Mo Sung, Yangsoo Jang, Namsik Chung, Ki-Chul Hwang, Tae Woong Kim

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LY 294002

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Specifications/Features

Promega

Citations (15)

Reviews

LY 294002 from Promega

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